许德麟

博士、教授、博士生导师

生态学系党总支书记  

—— 研究方向 ——

微生物群体感应调节与生物防控、肠道微生态与宿主免疫、水环境微生物资源开发利用、微生态制剂研发与替抗方案等。

—— 主要学习工作经历 ——

2012.10 至今     暨南大学生命科学技术学院 生态学系

2010.12 - 2011.12   香港浸会大学，博士后

2008.10 - 2010.10   法国巴黎第11大学，博士后

2004.09 –2008.02   韩国明知大学，生物学专业，博士

2002.09 –2004.08   韩国明知大学，环境工程与生物技术专业，硕士

—— 主讲课程 ——

【本科课程】：微生物学、生态学分子方法技术及应用、分子微生物学（全英）。

【研究生课程】：生态学研究方法

—— 主持的科研项目 ——

1.   国家自然科学基金（面上）：链霉菌SH5肠道定植及群感效应调节机制（编号：32271568），2023.01 ~ 2026.12

2.  广东省自然科学基金：链霉菌SH5防控嗜水气单胞菌感染的益生作用机制（编号：2023A1515012806）， 2023.01~2025.12

3.   国家重点研发计划子课题：基于牧食作用调控的富营养化水体生物修复技术研究（编号：2022YFE0122100），2023.01~2024.12

4.   国家自然科学基金重点项目--子课题：微生物介导作物吸收累积新兴有机污染物的环境生物地球化学机制（编号：42030713），2021.01 ~ 2025.12

5.   广州市科技计划项目（基础与应用基础）：潜在益生链霉菌株S073防治弧菌病机制的研究（编号：202102080372），2021.04~2023.03

6.   广东省科技计划项目：广东特色水产品生态养殖技术集成与示范指导项目（No.[2019]170），2019.10~2021.10

7.  广东省自然科学基金：铁载体介导的海洋链霉菌S073防控弧菌病机制的研究（编号：2019A1515011791），2019.10~2022.9

8.  广东省自然科学基金：乙酰转移酶SCO0988调控链霉菌抗生素合成的机理（编号：2018A030313578），2018.10~2021.10

9.  广东省自然科学基金：弧菌特异性抑制剂的筛选及防治弧菌病效果的研究（编号：2015A030313319），2015.10~2018.10

10. 国家自然科学基金（青年）：TetR家族蛋白，SCO3201，在天蓝色链霉菌和变铅青链霉菌中下游调控靶基因的鉴定及功能分析（编号：31300046），2014.01 ~ 2016.12

11. 广东省自然科学基金：链霉菌中对一TetR家族转录调控因子调控目标基因的鉴定（编号：S2013010013705)，2013.10 ~ 2015.10

12. 农业部南海渔业资源开发利用重点实验室开放基金：水霉拮抗放线菌的筛选及预防水霉感染效果研究（编号：LSF2013-07)，2013.08 ~ 2015.07

—— 发表论文 ——

1.    Yunwen Bi†, Hao An†, Zhewei Chi†, Zhongheng Xu, Yuan Deng, Yuxian Ren, Rui Wang, Xinyi Lu, Jia Guo*, Ren Hu*, Marie-Joelle Virolle* and Delin Xu*. (2024) The acetyltransferase SCO0988 controls positively specialized metabolism and morphological differentiation in the model strains Streptomyces coelicolor and Streptomyces lividans. Frontiers in Microbiology, 15:1366336. DOI: 10.3389/fmicb.2024.1366336

2.   Miao Cui, Gaojun Zheng, Xin Wu, Jiaying Zhang, Zibin Wang, Zhicong Pang, Shixu Wang, Ren Hu*, Delin Xu*. (2024) Microplastics’ vector effect on Co-bioaccumulation of it and polychlorinated biphenyls in Crassostrea hongkongensis. Ecotoxicology and Environmental Safety, 285 (2024) 117119.

3.    Ganxing Liu†, Hao An†, Lei Tang†, Zhewei Chi, Yunwen Bi, Zeqi Ye, Haiming Zhao, Lei Xiang, Naixian Feng*, Cehui Mo*, Delin Xu*. (2024) Activated DBP degradation and relevant signal transduction path via quorum sensing autoinducers in Streptomyces sp. SH5. Journal of Hazardous Materials. 466: 133571.

4.   Qiting Liang†, Ganxing Liu†, Zheng Guo†, Yuting Wang, Zhongheng Xu, Yuxian Ren, Qizhong Zhang*, Miao Cui*, Xinqing Zhao*, Delin Xu* (2022) Application of potential probiotic strain Streptomyces sp. SH5 on anti-Aeromonas infection in zebrafish larvae. Fish & Shellfish Immunology. 127: 375–385.

5.   Miao Cui*, Zibin Wang, Yongchun Yang, Ru Liu, Min Wu, Yujie Li, Qizhong Zhang and Delin Xu* (2022) Comparative Transcriptomic Analysis Reveals the Regulated Expression Profiles in Oreochromis niloticus in Response to Coinfection of Streptococcus agalactiae and Streptococcus iniae. Frontiers in Genetics. doi: 10.3389/fgene.2022.782957.

6.   Yunwen Bi, Ganxing Liu, Qiushi Yu, Qiting Liang, Zhongheng Xu, Miao Cui*, Qizhong Zhang*, Delin Xu*（2021）Anti-Vibrio dibutyl phthalate from marine-derived Streptomyces sp. S073. Research in Veterinary Science. 140: 198-202.

7.   Tinglong Hou†, Delin Xu†, Miao Cui, Huiru Liu, Yaowu Fu, Lingli Zhang, Lei Tang, Yanmeng Liu, Qizhong Zhang* (2020) The transcriptional factor GATA-4 negatively regulates Hsp70 transcription in Crassostrea hongkongensis. Molecular Biology Reports. 47:7107–7114. DOI: 10.1007/s11033-020-05778-9.

8.   Jun Zhang†, Qiting Liang†, Zhongheng Xu, Miao Cui, Qizhong Zhang1, Sonia Abreu, Michelle David, Clara Lejeune, Pierre Chaminade, Marie-Joelle Virolle, Delin Xu* (2020) The inhibition of antibiotic production in Streptomyces coelicolor over-expressing the TetR regulator SCO3201 is correlated with changes in the lipidome of the strain. Frontiers in Microbiology. doi: 10.3389/fmicb.2020.01399.

9.   Luoqiang Zhang†, Delin Xu†, Feifei Wang, Qizhong Zhang (2019) Antifungal activity of Burkholderia sp. HD05 against Saprolegnia sp. by 2-pyrrolidone-5-carboxylic acid. Aquaculture. 511:634198.

10.  Miao Cui, Huijie Zhang, Jingjing Li, Ru Liu, Min Wu, Delin Xu*, Qizhong Zhang* (2019) Differential PCR detection of Streptococcus agalactiae and Streptococcus iniae in tilapia (Oreochromis niloticus) by a single primer pair. Journal of Fish Diseases. 42(8):1211-1216.

11.  Mingxia Yang, Jun Zhang, Qiting Liang, Guanxin Pan, Jiachang Zhao, Miao Cui, Xinqing Zhao, Qizhong Zhang, Delin Xu* (2019) Antagonistic activity of marine Streptomyces sp. S073 on pathogenic Vibrio parahaemolyticus. Fisheries Science. 85:533–543.

12.  Delin Xu†, Di Wang†, Miao Cui, Qizhong Zhang* (2018) The purine-rich element-binding protein ChPur-α negatively regulates Hsc70 transcription in Crassostrea hongkongensis. Cell Stress and Chaperones. 23: 91-100.

13.  Huiru Liu†, Delin Xu†, Miao Cui, Tinglong Hou, Qizhong Zhang （2018）The transcriptional factor YB-1 positively regulates Hsc70 transcription in Crassostrea hongkongensis. Biochemical and Biophysical Research Communications. 495: 2404-2409.

14.  Lingli Zhang, Delin Xu, Miao Cui, Lei Tang, Tinglong Hou, Qizhong Zhang (2018) The guanine nucleotide-binding protein α subunit protein ChGnaq positively regulates Hsc70 transcription in Crassostrea hongkongensis. Biochemical and Biophysical Research Communications. 499: 215-220.

15.  Delin Xu†, Qin Yang†, Miao Cui and Qizhong Zhang (2017) The novel transcriptional factor HP1BP3 negatively regulates Hsp70 transcription in Crassostrea hongkongensis. Scientific Reports. | 7: 1401 | DOI:10.1038/s41598-017-01573-y

16.  Lan Yan, Qizhong Zhang, Marie-Joelle Virolle, Delin Xu* (2017) In conditions of over-expression, WblI, a WhiB-like transcriptional regulator, has a positive impact on the weak antibiotic production of Streptomyces lividans TK24. PLoS One. https://doi.org/10.1371/journal.pone.0174781

17.  Zongyu Miao†, Delin Xu†, Miao Cui, Qizhong Zhang (2016) High mobility group protein DSP1 negatively regulates HSP70 transcription in Crassostrea hongkongensis. Biochemical and Biophysical Research Communications. 474: 634-639

18.  Delin Xu, Miao Cui and Qizhong Zhang (2016) Transcriptional Activity of Full-Length and Truncated Metallothionein Promoters of Crassostrea hongkongensis in Response to Metal Stress. Journal of Shellfish Research. 35(1): 83-89

19.  Delin Xu†, Bo Yu, Yan Zhang, Miao Cui and Qizhong Zhang (2015) Metallothionein Protein Expression of Crassostrea hongkongensis in Response to Cadmium Stress. Journal of Shellfish Research. 34(2):311-318

20.  Delin Xu†, Paul Waack, Qizhong Zhang, Sebastiaan Werten, Winfried Hinrichs, Marie-Joelle Virolle (2014) Structure and regulatory targets of SCO3201, a highly promiscuous TetR-like regulator of Streptomyces coelicolor M145. Biochem Biophys Res Commun. 450 : 513–518.

21.  Ammaiyappan Selvam, Delin Xu, Zhenyong Zhao, Jonathan W.C. Won (2012) Fate of tetracycline, sulfonamide and fluoroquinolone resistance genes and the changes in bacterial diversity during composting of swine manure. Bioresource Technology. 126: 383-390

22.  Delin Xu†, Nicolas Seghezzi†, Catherine Esnault and Marie-Joelle Virolle (2010) Repression of antibiotic production and sporulation in Streptomyces coelicolor by overexpression of a TetR family transcriptional regulator. Appl. Environ. Microbiol.76 (23): 7741-53

23.  Delin Xu†, Tae-Jong Kim†, ZY Park, SK Lee, SH Yang, Hyung-Jin Kwon and Joo-Won Suh (2009) A DNA-binding factor, ArfA, interacts with the bldH promoter and affects undecylprodigiosin production in Streptomyces lividans. Biochem Biophys Res Commun. 379: 319-23

24.  Delin Xu, Hyung-Jin Kwon and Joo-Won Suh (2008) S-Adenosylmethionine induces BldH and activates secondary metabolism by involving the TTA-codon control of bldH expression in Streptomyces lividans. Arch Microbiol. 189: 419-26

25.  Su-Kyoung Shin†, Delin Xu†, Hyung-Jin Kwon & Joo-Won Suh (2006) S-Adenosylmethionine activates adpA transcription and promotes streptomycin biosynthesis in Streptomyces griseus. FEMS Microbio Lett 259: 53-59

—— 学术与社会兼职 ——

广东省水产学会理事。Frontiers in Environmental Sciences期刊编委，Aquaculture、Frontiers in Microbiology、Journal of Fish Disease等学术期刊审稿人。广东省/企业农村科技特派员，广州市农村科技特派员，广东省休闲渔业与垂钓协会智库专家。

—— 荣誉与奖励 ——

①  “第十届暨南大学教育教学成果奖”二等奖（第一完成人）、一等奖（第七完成人）

②  “2024第九届全国大学生生命科学竞赛（科学探究类）”，二等奖，指导教师

③ “2023广东省第十七届挑战杯科技竞赛（“绿美广东”专项赛）”，一等奖，指导教师

④ “2020全国大学生生命科学创新创业大赛”一等奖，指导教师

⑤ “2019全国大学生生命科学创新创业大赛”二等奖，指导教师

⑥ “2018全国大学生生命科学创新创业大赛”三等奖，指导教师

⑦   2020年度省级大学生创新创业训练计划项目，指导教师

⑧   2019年度国家级大学生创新创业训练计划项目，指导教师

⑨   暨南大学生命科学技术学院2019年度“本科教学突出个人贡献奖”

⑩   暨南大学本科教学校长奖（2015、2014）

⑪“暨南大学第六届本科课程全英语教学竞赛”二等奖（2015）

⑫“暨南大学首届新任教师本科教学竞赛”二等奖（2013）

⑬“暨南大学第六届本科课程教学竞赛”三等奖（2016）

⑭“暨南大学第八届本科课程教学竞赛”三等奖（2019）

⑮   生命科学技术学院2019年度“优秀班主任”